Use Of Karyotype Analysis In Genetic Counseling Biology Essay.

In this type of translocation, segments are exchanged between two non-homologous chromosomes, therefore, it involves one break in each of the involved chromosomes (Fig. 14.2). Most of the translocations are reciprocal translocations. Such translocations have been extensively studied in various plant and animal species. 3.

The article of Miyazaki et al. is a case report that involved an elderly male patient who was diagnosed with acute promyelocytic leukemia with unique chromosomal rearrangements. Aside from the hallmark translocation between chromosomes 15 and 17, the patient also carried additional chromosomes that were related to the aberration.

Reciprocal Chromosome Translocation - an overview.

Balanced translocations in both examples shown in the previous pictures, the chromosome material has been rearranged but no chromosome material has been lost or gained. This is known as a balanced translocation and does not usually affect the health of the person who carries it. The only time it is important to them is when they come to have children, when a baby can inherit what is called an.A translocation means that a piece of one chromosome has broken off and stuck on a different chromosome. Chromosome translocations cannot be repaired. If a translocation has not resulted in any genetic material being lost, it is known as a balanced translocation. The picture below shows how a balanced translocation happens.Translocation is a type of chromosomal abnormality in which a chromosome breaks and a portion of it reattaches to a different chromosome. Chromosomal translocations can be detected by analyzing karyotypes of the affected cells. Illustration. Narration. A translocation is a chromosomal abnormality whereby there's a break in the chromosome, one particular chromosome, and that chromosome will.


Translocations occur when chromosomes become broken during meiosis and the resulting fragment becomes joined to another chromosome. Reciprocal translocations: In a balanced reciprocal translocation (Fig. 2.3), genetic material is exchanged between two chromosomes with no apparent loss.The family chosen for this paper has a history of chromosome balanced and unbalanced translocation. A balanced translocation is a chromosomal abnormality that if unbalanced (too much or too little genetic material) can lead to infertility, multiple miscarriages, or a child with congenital abnormalities, developmental issues, etc.

A translocation means that a piece of one chromosome has broken off and stuck on a different chromosome. Chromosome translocations cannot be repaired. If a translocation has not resulted in any genetic material being lost, it is known as a balanced translocation. Balanced translocations do not usually cause any medical problems.

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This is not an example of the work produced by our Essay Writing Service. You can view samples of our. 2006). However, the main advantage from studying them comes from the fact that “translocations produce a definable genetic lesion” (Ross et al, 2006, p.146) meaning that one can study the effect of the resulting mutation by examining the final gene product. Ross et al, (2006, p.146.

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However, there will be a risk to the children of a carrier of a balanced translocation since that person is likely to produce unbalanced gametes (bearing too little or too much genetic information), and therefore the risk of having abnormal offspring is increased. Rearrangements such as aneuploidy may be found in all cells of an individual, or they may occur only in a percentage of an.

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Turner's syndrome and Down's syndrome are examples of chromosome abnormalities. In individuals with chromosome abnormalities, the karotype (a display of chromosomes within a single cell) is altered. Other examples of genetic disorders that result from chromosomal abnormalities are: Klinefelter Syndrome, Cri du chat Syndrome, Williams Syndrome, Reciprocal Translocation: Philadelphia Chromosome.

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Truly balanced translocations and inversions do not lead to the net loss of genetic material, therefore only affect the phenotype of the carrier if either a chromosome break has disrupted an important gene or a break affects the expression of a gene without disrupting its coding region, e.g. by juxtaposing the complete coding region of one gene to the control sequences of a different gene.

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Genetics essay example. Genetics and genomics is a fundamental component of science applicable for all nursing practices since basically all conditions and diseases have a genetic or genomic base. Patients’ health care usually include information on genetics and genomics along the trails of screening diagnostics, prevention, prognostics, disease treatment and evaluation of treatment.

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Parental chromosome analysis should be offered where trisomy 13 is due to an unbalanced translocation. 0 Macular translocation for a patient with age-related macular degeneration.

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This newly formed chromosome is called the translocation chromosome. The translocation in this example is between chromosomes 14 and 21. When a baby is born with this type of translocation chromosome in addition to one normal 14 and two normal 21 chromosomes, the baby will have Down syndrome. This is also called translocation Down syndrome.

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One of the best examples is chronic myelogenous leukemia (CML). Greater than 90% of individuals with CML carry a specific translocation, referred to as the Philadelphia chromosome, involving chromosomes 9 and 22. This translocation is not present in normal cells of these patients.

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For instance, using a chromosome 20 array with 22 cosmid, P1 phage artificial chromosome (PAC) and bacterial artificial chromosome (BAC) clones as intervals markers covering chromosome 20 at 3 Mb resolution, by using this array to study breast cancer it detected SeGAs in multiple regions suggesting that by using a higher density array it would be possible to gain more insight into the complex.

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